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Anti CCP ELISA kit



Full name

Human Anti CCP ELISA test kit

Category Name Autoimmune Disease kits
Test 96
Method Indirect Method
Principle Quantitative
Detection Range 1.12 AU/mL
Sample 100 uL
Specificity 79%
Sensitivity 97%
Total Time ~ 105 min.
Shelf Life 12-14 Months from the manufacturing date

Item #:                    3175-17   Quantity:               

Anti CCP ELISA kit

Anti ccp_3175-17(MSDS)(07-08-2016).pdf

Anti CCP ELISA kit

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Anti CCP ELISA kit description:

Diagnostic Automation Inc. offers Anti-CCP ELISA test kit which is an indirect solid-phase enzyme immunometric assay for the quantitative determination of IgG class antibodies directed against Cyclic Citrullinated Peptides (CCP), present in human serum or plasma. Anti-CCP test is based on the binding of the antibodies present in the sample, to the antigen coated on the microplate.

Material provided with Anti-CCP ELISA test kit:
1. Anti-CCP IgG ELISA Standards, STD1- STD 5, 5 vials, 1ml each
2. Anti-CCP IgG ELISA positive control, 1ml, ready to use
3. Sample diluent, 100ml
4. Anti-CCP IgG EIA conjugate, 15 ml
Sheep anti-human IgG HRP-conjugate
5. Anti-CCP IgG EIA coated Microplate
1 breakable microplate coated with Cyclic Citrullinated Peptides (CCP)
6. TMB substrate, 15ml
7. Stop solution, 15 ml
8. Anti-CCP IgG ELISA wash solution, 100ml, 10x

Materials & Instrumentation required, not included:
1. Distilled water
2. Automated dispenser
3. Microplate ELISA Washer
4. Microplate ELISA Reader, 450nm

Anti-CCP ELISA test Background Information:
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases in European population. The most significant clinical symptom is an inflammation of the synovial membranes which causes a painful swelling of the articulations and ankylosis. Abnormal antibodies (immune proteins) are found in the blood of patients with RA. An antibody called Rheumatoid Factor (RF) can be detected in 80% of patients with RA. Another antibody which is present in the blood of most RA patients is Citrulline antibody which is also known as anticitrulline antibody, anticyclic citrullinated peptide antibody, and anti-CCP are associated with more aggressive forms of RA. The advantage of the Anti CCP antibodies is that they are detectable in the patient sera up to 10 years prior to the appearance of symptoms and are characterized by a specificity of over 90%-95% in patients affected by RA. Moreover, the presence of Anti CCP antibodies can be used in the diagnosis of juvenile RA. The Anti CCP antibodies test has an important prognostic value in the monitoring of articular radiologically detectable damage. The kits quantitative determination is useful in the control and verification of the effects of pharmacological therapy. The Anti CCP antibody test, together with the determination of RF increases the ratio of sensitivity/specificity. 20% of the RAs are RF-negative and 15/20% of the RAs are positive only to RF. The simultaneous positive result of a sample to RF and CCP has a positive predictive value of about 100%.

Anti-CCP test is particularly useful for:
1. diagnosis of juvenile RA
2. diagnosis of RA in patients with unexplained joint inflammation
3. diagnosis of RA in previously undiagnosed inflammatory arthritis in patients where traditional tests were negative

The Anti-CCP IgG ELISA kit, like many ELISA KITS, is for in-vitro diagnostic & laboratory use only. See the Anti-CCP IgG ELISA kit product insert for details on preparation, procedures, quality control, and test result interpretation.

Diagnostic Automation Inc. also provides other Autoimmune ELISA Kits. For more information about these ELISA Kits or Rapid Test, IFA Kit, CLIA Test Kit, or Serology test, please see our website home page, or contact our Customer Service Representative at 818-591-3030.